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September 22, 2021

Friends of Physiology Lecture19:00 – 19:30 EST

Welcome and Opening Remarks
Crina Nimigean, President, Society of General Physiologists
Stefan Feske, Conference Organizer
Introduction by Richard Lewis, PhD, Stanford University, Stanford, CA

Keynote Address19:30 – 20:30 EST

Ion Channels in T Lymphocytes: A Single Cell Approach to Immunology

Michael Cahalan, PhD

University of California, Irvine, CAVIRTUAL TALK

September 23, 2021

Session 1: Ion Channels & Transporters (ICTs) in Lymphocytes
8:00-10:00 EST

NAADP and Ca2+ Signaling in T Cells

Andreas Guse, MD

University Medical Center Hamburg-Eppendorf, Hamburg, GermanyVIRTUAL TALK

TRPM7 and Other Ion Channels in B Cell Function

Bebhinn Treanor, PhD

University of Toronto Scarborough, CanadaVIRTUAL TALK

CRAC Channels in B-cells

Mohamed Trebak, PhD

University of Pittsburgh, Pittsburgh, PA

NKD2 Regulates ORAI1 Trafficking and CRAC Channel Function

Yousang Gwack, PhD

David Geffen School of Medicine at UCLA, Los Angeles, CA

Data Blitz 1

4 Snapshot Poster PresentationsVIRTUAL TALK

Session 2: ICTs in Innate Immunity 110:30-11:55 EST

TRPM2, Linking Oxidative Stress and Ca2+ Permeation to NLRP3 Inflammasome Activation

Longfei Wang, PhD

Harvard Medical School, Boston, MAVIRTUAL TALK

Mitochondrial Ca2+ Signaling in Cell Intrinsic Immune Responses

Bimal Desai, PhD

University of Virginia, Charlottesville, VA

Orai Channel C-terminal Peptides – Calcium Signal Suppression and Potential for Immunomodulation

Donald Gill, PhD

Penn State University, State College, PA

The Volume Regulated Anion Channel LRRC8C Suppresses T Cell Function by Regulating Cyclic Dinucleotide Transport and STING-p53 Signaling

Axel Concepcion, PhD

New York University, New York, NY

Data Blitz 2

4 Snapshot Poster Presentations

Round Table 114:00-15:00 EST

Career Development and Increasing Diversity

Poster Session 1, In-Person15:00-17:00 EST

Authors at Posters for discussion with attendees

Session 3: Novel Structures of ICTs in Immune Cells19:00-21:00 EST

EXCELSIOR AWARD LECTURE

Mechanosensation by PIEZO1 Is Essential for Innate Immunity

Angel Solis, PhD

Gettysburg College, Gettysburg, PA

Structural Studies Reveal Insights into CRAC Channel Activation

Xiaowei Hou, PhD

Memorial Sloan Kettering Cancer Center, New York, NY

The Mitochondrial Calcium Uniporter: Pore Structure and Regulation by MICU1/MICU2

Stephen Long, PhD

Memorial Sloan Kettering Cancer Center, New York, NY

Ligand Recognition and Gating Mechanism of Temperature Sensitive TRPM Channels

Juan Du, PhD

Van Andel Institute, Grand Rapids, MIVIRTUAL TALK

September 24, 2021

Session 4: ICTs in Lymphocytes and Antitumor Immunity8:15-10:00 EST

Potassium Channel Role in Anti-tumor Immunity

Laura Conforti, PhD

University of Cincinnati, Cincinnati, OHVIRTUAL TALK

Synthetic Biology Approaches to Regulate T Cell Mediated Immunity to Cancer

Yubin Zhou, MD, PhD

Center for Translational Cancer Research, Texas A&M, Houston, TXVIRTUAL TALK

Otopetrin Proton Channels: What, Where, Why and How

Emily Liman, PhD

University of Southern California, Los Angeles, CA

Regulation of Immune Cell Function by Ion Channels

Stefan Feske, MD

NYU Grossman School of Medicine, New York, NY

Session 5: ICTs in Innate Immunity 210:30-12:10 EST

Under-appreciated Role of Mechanotransduction in Vivo

Shang Ma, PhD

University of California, San Diego, CA

Membrane Potential Modulates Neutrophil Calcium Signaling in Development and Inflammation

Regina Clemens, MD, PhD

Washington University School of Medicine, St. Louis, MO

Calcium-dependent and Independent Roles of Membrane Contact Sites During Phagocytosis

Paula Nunes-Hasler, PhD

University of Geneva, Geneva, SwitzerlandVIRTUAL TALK

Endolysosomal TRP Channels and TPCs in Immune Cell Function and Disease

Christian Grimm, PhD

Ludwig-Maximilians-University Munich, GermanyVIRTUAL TALK

Data Blitz 3

5 Snapshot Poster PresentationsVIRTUAL TALK

Round Table 214:00-15:00 EST

Ion Channels & Transporters as Drug Targets in Immunity and Inflammation

Poster Session 215:00-17:00 EST

Authors at Posters for discussion with attendeesVIRTUAL SESSION

Session 6: Cell Biological Aspects of ICTs in Immune Cells19:00-21:00 EST

Lipid Regulation of Monovalent Channels in Immune Surveillance

Sergio Grinstein, PhD

Hospital for Sick Children, Toronto, CanadaVIRTUAL TALK

Interplay Between KCa1.1 and Cav1.2 Channels in Synovial Fibroblasts in Rheumatoid Arthritis

Christine Beeton, PhD

Baylor College of Medicine, Houston, TXA

TRPM2 During The Inflammatory Response of Phagocytic Cells: Friend or Foe

Santiago Partida-Sanchez, PhD

Abigail Wexner Research Institute at Nationwide Children's Hospital & The Ohio State University College of Medicine, Columbus, OH

Suppression of Ca2+ Signals by EGR4 Controls Th1 Differentiation and Anti-cancer Immunity In Vivo

Jonathan Soboloff, PhD

Temple University, Pennsylvania, PA

Mechanically Activated Ion Channel Piezo1 Modulates Macrophage Polarization and Stiffness Sensing

Wendy Liu, PhD

University of California, Irvine, CAVIRTUAL TALK

Method of Measuring the Membrane Potential of Phagosomes by Optical Imaging

Yoshifumi Okochi, PhD

Osaka University, JapanVIRTUAL TALK

September 25, 2021

Session 7: Pathophysiological Roles of ICTs in Inflammation8:00-10:00 EST

Pannexin-1 Channels Promote Neuroinflammation After Brain Trauma

Jorge Contreras, PhD

The University of California Davis, Sacramento, CA

Microglial CRAC Channels and Neuroinflammation

Murali Prakriya, PhD

Northwestern University, Chicago, IL

Solute Carrier Proteins in Macrophages Enable Efferocytosis by Promoting Glucose Uptake and Lactate Release

Kodi Ravichandran, PhD

University of Virginia, Charlottesville, VAVIRTUAL TALK

Ezyme-coupled TRP Channels and Endolysosomal TPCs in Immune Homeostasis

Susanna Zierler, PhD

Johannes Kepler University Linz, AustriaVIRTUAL TALK

Session 8: Modulation of Immune Cell Function by ICTs10:30-12:00 EST

Ion Channels Regulating Neural-Immune Interactions in Host Defense and Immunity

Isaac Chiu, PhD

Harvard Medical School, Boston, MA

The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-induced Inflammation

Asrar Malik, PhD

University of Illinois at Chicago, Chicago, ILVIRTUAL TALK

cGAMP as an Immunotransmitter and its Transporters

Lingyin Li, PhD

Stanford University, Stanford, CAVIRTUAL TALK

Session 9: Ion Channels as Drug Targets in Immune Diseases17:00-18:45 EST

CRAC Channels in Mast Cell Function and Allergy

Anant Parekh, PhD

Oxford University, EnglandVIRTUAL TALK

Illuminating Dark and Druggable Genome

Olga Gulyaeva, PhD

University of California, San Francisco, CA

Targeting TRP Channels for Immune Modulation

Andrea Fleig, PhD

University of Hawaii Cancer Center, Honolulu, HI

CRAC Channels as Targets for Drug Discovery and Development

Kenneth Stauderman, PhD

CalciMedica, Inc. La Jolla, CA